doi: 10.16306/j.1008-861x.2009.04.024, Qin, R., Li, X., Li, G., Tao, L., Li, Y., Sun, J., et al. doi: 10.3892/ijmm.2017.3157, Löhle, M., and Reichmann, H. (2010). It alleviates shuddering that is a common symptom of Parkinson’s disease. This herb contains anti-spasmodic properties and is a natural sedative that proves to be helpful in treating symptoms of Parkinson’s disease. Aust. 181, 293–294. Compared with placebo groups, HM paratherapy (n = 16 comparisons) showed significant better effects in the assessments of total Unified Parkinson's Disease Rating Scale (UPDRS) (WMD: −5.43, 95% CI:−8.01 to −2.86; P < 0.0001), UPDRS I (WMD: −0.30, 95% CI: −0.54 to −0.06; P = 0.02), UPDRS II (WMD: −2.21, 95% CI: −3.19 to −1.22; P < 0.0001), UPDRS III (WMD: −3.26, 95% CI:−4.36 to −2.16; P < 0.00001), Parkinson's Disease Quality of Life Questionnaire (p < 0.01) and Parkinson's Disease Questionnaire-39 (WMD: −7.65, 95% CI: −11.46 to −3.83; p < 0.0001), Non-motor Symptoms Questionnaire (p < 0.01) and Non-Motor Symptoms Scale (WMD: −9.19, 95% CI: −13.11 to −5.28; P < 0.00001), Parkinson's Disease Sleep Scale (WMD: 10.69, 95% CI: 8.86 to 12.53; P < 0.00001), and Hamilton depression rating scale (WMD: −5.87, 95% CI: −7.06 to −4.68; P < 0.00001). J. Biol. Another study by Pennsylvania State University College of Medicine applied brahmi seed powder to rodent models of Parkinson’s. Specifically, seven studies (Pan et al., 2009, 2011; Guo et al., 2014; Wen et al., 2015; Yu, 2016; Cai et al., 2017; Yang, 2017) used random number tables. doi: 10.7326/M16-2977, Chong, C. M., Zhou, Z. Y., Razmovski-Naumovski, V., Cui, G. Z., Zhang, L. Q., Sa, F., et al. Risk of bias of the included studies. The herbs with cumulative frequencies over 50% are documented and ranked. AS-IV (Liu et al., 2017) inhibited the expression of the α-syn via the p38 MAPK signaling pathway. Pharmacother. Econ. Eleven RCTs (Guo, 2010; Kum et al., 2011; Pan et al., 2011, 2013; Zhao et al., 2013; Chen M. Y. et al., 2014; Guo et al., 2014; Li et al., 2016; Yu, 2016; Cai et al., 2017; Yang, 2017) reported adverse events, among them 3 studies (Pan et al., 2011, 2013; Guo et al., 2014) reported no adverse events. UPDRS IV: Meta-analysis of 5 studies (Pan et al., 2009, 2011; Kum et al., 2011; Chen M. Y. et al., 2014; Cai et al., 2017) with 6 comparisons revealed that HM paratherapy did not significantly improve UPDRS IV relative to placebo (WMD: −0.18, 95% CI: −0.37 to −0.01, P = 0.06; heterogeneity: Chi2 = 5.76, P = 0.33, I2 = 13%; Figure 3D). Get Dr. Group's Immunity Strengthening Guide, Certified organic virgin cold pressed coconut oil, Green tea may protect brain cells against parkinson's disease, Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease, Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate, Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: therapeutic perspectives, Turmeric and Black Pepper: A Winning Combination, The Benefits of Turmeric for Prostate Health, Curcumin Benefits: Understanding This Powerful Antioxidant. Finally, different types and stages of PD can influence disease progression and response to treatment (Reinoso et al., 2015). These trials reported the detailed randomized methods; placebo-controlled group accounts for the placebo effects that don't depend on the treatment itself (Chen et al., 2017), and thus increasing the reliability of experiment results. However, a unified hypothesis does not currently exist for either receptor because there is too much conflicting data on the effectiveness of cannabinoids and these receptors. Based on the high-frequency used herbs, the anti-PD mechanisms of the main active ingredients of herbs in vivo or in vitro trails are as follows: (1) Antioxidant: Danshensu (from Radix Salviae Miltiorrhizae), catalpol (from Radix Rehmanniae), 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside (TSG) (from Radix Polygoni Multiflori), morroniside (from Fructus Corni) and astragaloside IV (AS-IV) (from Radix Astragali seu Hedysari) were shown to alleviate oxidative stress through reducing reactive oxygen species (ROS) level (Bi et al., 2008a; Sun et al., 2011; Chong et al., 2013; Liu et al., 2017; Zhang et al., 2017). (2017). Keep Sharing the Awareness, herbs are truly gift from God. 80, 193–199. doi: 10.3390/ijms17060904, Sun, F. L., Zhang, L., Zhang, R. Y., and Li, L. (2011). Med. Impact Factor 4.362 | CiteScore 6.3More on impact ›, Integrative approach to Parkinson’s disease BMJ 343:d5928. When testing medical marijuana, the dosage administered can vary dramatically depending on the plant and method of administration. Alternat. 17:E904. Parkinson’s disease is a type of neurodegenerative disorder that impairs the brain neurons. J. Neuroimmune Pharmacol. Mov. You can feel confident in knowing that the information within this article is sound. Fourteen included studies (Pan et al., 2009, 2011, 2013; Zhao et al., 2009, 2013; Guo, 2010; Kum et al., 2011; Chen M. Y. et al., 2014; Guo et al., 2014; Wen et al., 2015; Li et al., 2016; Yu, 2016; Cai et al., 2017; Yang, 2017) were published between 2009 and 2017. Parkinson’s is a chronic, progressive movement disorder for which there is no known cause or cure. doi: 10.1136/bmj.j1951, Sarkar, S., Raymick, J., and Imam, S. (2016). This natural sedative contains flavonoids, 8-pyrone derivatives and alkaloids. Neurol. “[O]ur results provide a new perspective and method for revealing the mechanism of action of Traditional Chinese Medicine prescriptions,” the researchers concluded. 15 Natural Herbs For Parkinson’s Disease Ginkgo Biloba. doi: 10.5114/fn.2012.30527, Tian, Y. Y., An, L. J., Jiang, L., Duan, Y. L., Chen, J., and Jiang, B. Catalpol, and tetramethylpyrazine (TMP) (from Rhizoma Ligustici Chuanxiong) prevented the decrease in the activities of superoxide dismutase, catalase and glutathione peroxidase, and inhibited malondialdehyde overproduction (Bi et al., 2008a; Lu et al., 2014; Li et al., 2016).

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